Allium sativum: rediscovering its culinary and medicinal heritage

Authors

  • Ananta Choudhury Faculty of Pharmaceutical Science, Assam down town University, Panikhaiti, Guwahati, Assam, 781026
  • Siraj Ahmed Mahatma Gandhi University, Ri Bhoi, Meghalaya
  • Biprojit Paul NEMCARE Group of Institutions, Mirza, Guwahati, Assam

Keywords:

Garlic, medicinal plants, pharmacological use, traditional use, anti-cancer

Abstract

Since the early beginning of mankind, medicinal plants have played a crucial role in human healthcare, serving as ingredients in traditional medicines, spices, and food components. Among these botanical treasures is Allium sativum L., commonly known as Garlic, a highly revered herb and spice derived from tubers. Garlic is a valuable herb with a rich history of culinary and traditional medicinal applications worldwide. Extensive scientific investigation has explored the wide array of biological activities associated with A. sativum, including its antioxidant, blood sugar-regulating, anti-inflammatory, cholesterol-lowering, anti-cancer, antithrombotic, antidiabetic, antihypertensive, obesity-regulatory, antimicrobial, and liver-protective properties, as substantiated by previous studies. A. sativum is renowned for its effectiveness in addressing a wide range of health issues, including cardiovascular conditions, cancer progression, rheumatism, diabetes, intestinal parasites, bloating, colic, dysentery, liver disorders and various other ailments. This review thoroughly examines updated data till last year of both traditional and therapeutic activities including anti-inflammatory, anti-cancer, and antimicrobial of Allium sativum.

References

Subroto, E., et al. "Bioactive compounds in garlic (Allium sativum L.) as a source of antioxidants and its potential to improve the immune system: a review." Food Res 5.1 (2021): 10-26656.

Charu, K., S. Yogita, and S. Sonali. "Neutraceutical potential of organosulfur compounds in fresh garlic and garlic preparations." Int. J. Pharm. Bio. Sci 5.1 (2014): 112-126.

Qiu, Zhichang, et al. "Bioactive polysaccharides and oligosaccharides from garlic (Allium sativum L.): Production, physicochemical and biological properties, and structure–function relationships." Comprehensive Reviews in Food Science and Food Safety 21.4 (2022): 3033-3095.

Rouf, Razina, et al. "Antiviral potential of garlic (Allium sativum) and its organosulfur compounds: A systematic update of pre-clinical and clinical data." Trends in food science & technology 104 (2020): 219-234.

Bhatwalkar, Sushma Bagde, et al. "Antibacterial properties of organosulfur compounds of garlic (Allium sativum)." Frontiers in Microbiology 12 (2021): 1869.

Myneni, Ajay A., et al. "Raw garlic consumption and lung cancer in a Chinese population." Cancer Epidemiology, Biomarkers & Prevention 25.4 (2016): 624-633.

Guercio, Valentina, et al. "Gastric cancer and allium vegetable intake: a critical review of the experimental and epidemiologic evidence." Nutrition and cancer 66.5 (2014): 757-773.

Tesfaye, Azene, and Worku Mengesha. "Traditional uses, phytochemistry and pharmacological properties of garlic (Allium Sativum) and its biological active compounds." Int. J. Sci. Res. Eng. Technol 1 (2015): 142-148.

Rahman, Khalid, and Gordon M. Lowe. "Garlic and cardiovascular disease: a critical review." The Journal of nutrition 136.3 (2006): 736S-740S.

Davis, Stephen R. "An overview of the antifungal properties of allicin and its breakdown products–the possibility of a safe and effective antifungal prophylactic." Mycoses 48.2 (2005): 95-100.

Badal, Dipankar Singh, et al. "Effect of organic manures and inorganic fertilizers on growth, yield and its attributing traits in garlic (Allium sativum L.)." Journal of pharmacognosy and phytochemistry 8.3 (2019): 587-590.

Souza, Gisele A., et al. "N-acetylcysteine an allium plant compound improves high-sucrose diet-induced obesity and related effects." Evidence-Based Complementary and Alternative Medicine 2011 (2011).

Ross, Z. M., et al. "Antimicrobial properties of garlic oil against human enteric bacteria: evaluation of methodologies and comparisons with garlic oil sulfides and garlic powder." Applied and environmental microbiology 67.1 (2001): 475-480.

Kuda, Takashi, Akiko Iwai, and Toshihiro Yano. "Effect of red pepper Capsicum annuum var. conoides and garlic Allium sativum on plasma lipid levels and cecal microflora in mice fed beef tallow." Food and chemical toxicology 42.10 (2004): 1695-1700.

Cutler, R. R., and P. Wilson. "Antibacterial activity of a new, stable, aqueous extract of allicin against methicillin-resistant Staphylococcus aureus." British journal of biomedical science 61.2 (2004): 71-74.

Wallock-Richards, Daynea, et al. "Garlic revisited: antimicrobial activity of allicin-containing garlic extracts against Burkholderia cepacia complex." PLoS One 9.12 (2014): e112726.

Mikaili, Peyman, et al. "Therapeutic uses and pharmacological properties of garlic, shallot, and their biologically active compounds." Iranian journal of basic medical sciences 16.10 (2013): 1031.

Meriga, Balaji, Ramgopal Mopuri, and T. MuraliKrishna. "Insecticidal, antimicrobial and antioxidant activities of bulb extracts of Allium sativum." Asian Pacific journal of tropical medicine 5.5 (2012): 391-395.

Shokrzadeh, M., and A. G. Ebadi. "Antibacterial effect of garlic (Allium sativum L.) on Staphylococcus aureus." Pak. J. Biol. Sci 9.8 (2006): 1577-9.

Gruhlke, M. C., et al. "Allicin from garlic, effective in controlling several plant diseases, is a reactive sulfur species (RSS) that pushes cells into apoptosis." Modern fungicides and antifungal compounds VI. 16th International Reinhardsbrunn Symposium, Friedrichroda, Germany, April 25-29, 2010. Deutsche Phytomedizinische Gesellschaft eV Selbstverlag, 2011.

Locatelli, Daniela Ana, et al. "Cooked garlic and antioxidant activity: Correlation with organosulfur compound composition." Food chemistry 220 (2017): 219-224.

Zakarova, Alexandra, et al. "Garlic sprouting is associated with increased antioxidant activity and concomitant changes in the metabolite profile." Journal of Agricultural and Food Chemistry 62.8 (2014): 1875-1880.

Jang HJ, et al. Antioxidant and antimicrobial activities of fresh garlic and aged garlic by-products extracted with different solvents. Food Science and Biotechnology, 27, 219-225 (2018).

Naji KM, et al. Hepatoprotective and antioxidant effects of single clove garlic against CCl4-induced hepatic damage in rabbits. BMC Complementary and Alternative Medicine, 17, 1-12 (2017).

Li Z, Le W, Cui Z. A novel therapeutic anticancer property of raw garlic extract via injection but not ingestion. Cell Death Discovery, 4, 108 (2018).

Shang A, et al. Bioactive compounds and biological functions of garlic (Allium sativum L.). Foods, 8, 246 (2019).

Gruhlke MCH, et al. The effects of allicin, a reactive sulfur species from garlic, on a selection of mammalian cell lines. Antioxidants, 6, 1 (2016).

Chhabria SV, et al. In situ allicin generation using targeted alliinase delivery for inhibition of MIA PaCa-2 cells via epigenetic changes, oxidative stress and cyclin-dependent kinase inhibitor (CDKI) expression. Apoptosis, 20, 1388-1409 (2015).

Fleischauer AT, Arab L. Garlic and cancer: a critical review of the epidemiologic literature. The Journal of Nutrition, 131, 1032S-1040S (2001).

Piscitelli SC, et al. The effect of garlic supplements on the pharmacokinetics of saquinavir. Clinical Infectious Diseases, 34, 234-238 (2002).

Bayan L, Koulivand PH, Gorji A. Garlic: a review of potential therapeutic effects. Avicenna Journal of Phytomedicine, 4, 1 (2014).

Iwalokun BA, et al. In vitro antimicrobial properties of aqueous garlic extract against multidrug-resistant bacteria and Candida species from Nigeria. Journal of Medicinal Food, 7, 327-333 (2004).

Daniel CK, Lennox CL, Vries FA. In-vitro effects of garlic extracts on pathogenic fungi Botrytis cinerea, Penicillium expansum and Neofabraea alba. South African Journal of Science, 111, 1-8 (2015).

Abdallah EM. Potential antifungal activity of fresh garlic cloves (Allium sativum L.) from Sudan. Journal of Biotechnology Research, 3, 106-109 (2017).

Hailu G, Bitew M, Temesgen M. In vitro antifungal activity of Croton macrostachys and Allium sativum extracts against Candida albicans and Trichophyton mentagrophytes isolates. International Journal of Biotechnology and Food Science, 5, 42-47 (2017).

Hussein HJ, Hameed IH, Hadi MY. A Review: Anti-microbial, Anti-inflammatory effect and Cardiovascular effects of Garlic: Allium sativum. Research Journal of Pharmacy and Technology, 10, 4069-4078 (2017).

You BR, et al. Anti-inflammatory effect of aged black garlic on 12-O-tetradecanoylphorbol-13-acetate-induced dermatitis in mice. Nutrition Research and Practice, 13, 189-195 (2019).

Galicia-Garcia U, et al. Pathophysiology of type 2 diabetes mellitus. International Journal of Molecular Sciences, 21, 6275 (2020).

Faroughi F, et al. Effects of garlic pill on blood glucose level in borderline gestational diabetes mellitus: a randomized controlled trial. Iran Red Crescent Medical Journal, 20, (2018).

Makheja AN, Bailey JM. Antiplatelet constituents of garlic and onion. Agents and Actions, 29, 360-363 (1990).

Subramanian MS, et al. Prevailing knowledge on the bioavailability and biological activities of sulphur compounds from alliums: a potential drug candidate. Molecules, 25, 4111 (2020).

Ansari F, et al. Study of garlic effect on fibrinolytic activity of the blood clot in vitro. (2011): 48-52.

Teranishi K, et al. Inhibition of baboon platelet aggregation in vitro and in vivo by the garlic derivative, ajoene. Xenotransplantation, 10, 374-379 (2003).

Kwak JS, et al. Garlic powder intake and cardiovascular risk factors: a meta-analysis of randomized controlled clinical trials. Nutrition Research and Practice, 8, 644-654 (2014).

Romeilah RM, Fayed SA, Mahmoud GI. Chemical compositions, antiviral and antioxidant activities of seven essential oils. Journal of Applied Sciences Research, 6, 50-62 (2010).

Subramanian MS, et al. Prevailing knowledge on the bioavailability and biological activities of sulphur compounds from alliums: a potential drug candidate. Molecules, 25, 4111 (2020).

Ried K. Garlic lowers blood pressure in hypertensive subjects, improves arterial stiffness and gut microbiota: A review and meta-analysis. Experimental and Therapeutic Medicine, 19, 1472-1478 (2020).

Ried K, Fakler P. Potential of garlic (Allium sativum) in lowering high blood pressure: mechanisms of action and clinical relevance. Integrated Blood Pressure Control, (2014): 71-82.

Lee MS, et al. Reduction of body weight by dietary garlic is associated with an increase in uncoupling protein mRNA expression and activation of AMP-activated protein kinase in diet-induced obese mice. The Journal of Nutrition, 141, 1947-1953 (2011).

Lai YS, et al. Garlic essential oil protects against obesity-triggered nonalcoholic fatty liver disease through modulation of lipid metabolism and oxidative stress. Journal of Agricultural and Food Chemistry, 62, 5897-5906 (2014).

Miura A, et al. Diallyl trisulfide prevents obesity and decreases miRNA?335 expression in adipose tissue in a diet?induced obesity rat model. Molecular Nutrition & Food Research, 65, 2001199 (2021).

Nathan M. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Annals of Internal Medicine, 130, 459 (1999).

Papageorgiou C, et al. Allergic Contact Dermatitis to Garlic (Allium Sativum L.). Identification of the Allergens: The Role of Mono-, Di-, and Trisulfides Present in Garlic. A Comparative Study in Man and Animal (Guinea-Pig). Archives of Dermatological Research, 275, 229-234 (1983).

McGovern TW, LaWarre S. Botanical Briefs: Garlic--Allium Sativum. Cutis, 67, 193-194 (2001).

Capasso F. Phytotherapy: A Quick Reference to Herbal Medicine. Springer Science & Business Media, (2003).

Ernst E, et al. The Desktop Guide to Complementary and Alternative Medicine: An Evidence-Based Approach. Mosby International Ltd, (2001).

Downloads

Published

2024-06-11

How to Cite

Choudhury, A. ., Ahmed, S., & Paul, B. (2024). Allium sativum: rediscovering its culinary and medicinal heritage. Journal of Applied Pharmacognosy and Phytochemistry, 4(1), 20-26. Retrieved from https://joapponline.com/index.php/joapp/article/view/52

Issue

Section

Articles