In vitro antioxidant, anti-inflammatory and anti-diabetic activity of Prunus undulata buch. -Ham.ex d don leaves
Keywords:
Prunus undulata Buch. -Ham.ex D Don, Antioxidant Activity, Anti-Inflammatory, Antidiabetic ActivityAbstract
The aim of this research work was to investigate the in-vitro antioxidant, Anti-inflammatory and anti-diabetic activity of methanol extracts of Prunus undulata Buch. -Ham.ex D Don leaves. Phytochemical screening of methanol extract of Prunus undulata Buch. -Ham.ex D Don were analysed by using standard methods. In-vitro Antioxidant activity of the methanol extracts of Prunus undulata Buch. -Ham.ex D Don leaves was characterized for DPPH (2, 2-diphenyl-1-picrylhydrazy), Reducing power, and hydrogen peroxide radical scavenging activity. In-vitro Anti-inflammatory activity such as membrane stabilization and inhibition of protein denaturation analysis was performed in methanol extract. In-vitro Antidiabetic activity such as inhibition of alpha amylase enzyme were carried in methanol extract. The phytochemical screening of methanol extract of Prunus undulata contains the presence of carbohydrate, Flavonoids, phenol, saponin, steroids and Triterpenoids. The methanol extracts of Prunus undulata Buch. -Ham.ex D Don showed potential antioxidant activity in all the assays tested. In-vitro Anti-inflammatory and Antidiabetic activity of Prunus undulata Buch. -Ham.ex D Don was also confirmed. The outcome of the present study concluded that the methanol extracts of Prunus undulata Buch. -Ham.ex D Don leaves possess significant antioxidant, anti-inflammatory and antidiabetic activity. The potential pharmacological activity of Prunus undulata Buch. -Ham.ex D Don leaves might be due to the presence of phytochemicals.
References
Sawmliana M, Zakhuma P. The book of Mizoram plants Chanmari west, Aizawl. P277 (2003).
Moualek I, Aiche GI, Guechaoui NM, Lahcene S, Houali K. Antioxidant and anti-inflammatory activities of Arbutus unedo aqueous extract. Asian pac J Trop Biomed., 6, 1-8 (2012).
Chanda S, Chatterjee P, Dey P and Bhattacharya S. Evaluation of in vitro inflammatory activity of coffee against the denaturation of protein. Asian Pacific J. Trop. Biomed., 6, 178-180 (2012).
Kumar S, Kumar D, Manjusha, Kamal Saroha, Nidhan Singh. Antioxidant free radical scavenging potential of Citrullus colocynthis (L) Schrad Methanolic fruit extract. Acta pharma., 58, 215-220 (2008).
Mitic VD, Stankov-Jovanovic VP, Jovanovic OP, Palic IR, Djordjevic AS, Stojanovic GS. Composition and antioxidant activity of hydrodistilled essential oil of Serian Ajuga chamaepitys (L.) Schreer ssp. Chia (Schreer) Arcangeli. JEOR, 23, 70-74 (2011).
Ruch Rj, Cheng SJ, Klaunig JE. Prevention of cytotoxicity and inhibition of intracellular communication by antioxidant catechins isolated from Chinese green tea. Carcinogenesis, 10, 1003-1008 (1989).
Oyaizu M. Studies on products of browning reactions: antioxidants activities of products of browning reaction prepared from glucose amine. Jap J. Nutr., 44, 307-315 (1986).
Gunathilake KDP P, Ranaweera KKDS and Vasantha Rupasinghe HP. In vitro Anti-inflammatory properties of delected green leafy vegetales. Biomedicines, 6, 107 (2018).
Mohammed Saleem TK, Azeem Ak, Sankar C, Prasanth NV, Duraisami R. Anti-inflammatory activity of the leaves extracts of Gendarrussa vulgaris Nees. Asian Pac J Trop Biomed., 1(2), 147-149 (2011).
Bhatnagar S, Sahoo M. Cytotocity and antidiabetic activity of leaf extracts of Paedaria foetida L. Int. J. of pharmacognosy and phytochemical Res., 8(4), 659-662 (2016).
Chung YC, Chang CT, Choa WW, Lin CF, Chou ST. Antioxidative activity and safety of the 50% ethanolic extract from red bean fermented by bacillus subtilis IMR-NK1. J. of agri. and food chemistry, 50, 2450-2454 (1981).
Sundriyal M and Sundriyal RC. Wild edible plants of the Sikkim Himalaya: Nutritive values of selected species. Eco. Bot., 58, 286-299 (2004).
Barrett ML, Udani JK. A proprietary alpha-amylase inhibitor from white bean (Phaseolus vulgaris): a review of clinical studies on weight loss and glycemic control. Nutr J., 10, 24 (2011).
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Vicky Bareh, A. Imtilemla, Samia Begam Bharbhuiya, Lalzikpuii Sailo
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
In submitting an article to Journal of Applied Pharmacognosy and Phytochemistry (JOAPP) I certify that:
- I am authorized by my co-authors to enter into these arrangements.
- I warrant, on behalf of myself and my co-authors, that:
- the article is original, has not been formally published in any other peer-reviewed journal, is not under consideration by any other journal and does not infringe any existing copyright or any other third party rights;
- I am/we are the sole author(s) of the article and have full authority to enter into this agreement and in granting rights to JOAPR are not in breach of any other obligation;
- the article contains nothing that is unlawful, libellous, or which would, if published, constitute a breach of contract or of confidence or of commitment given to secrecy;
- I/we have taken due care to ensure the integrity of the article. To my/our - and currently accepted scientific - knowledge all statements contained in it purporting to be facts are true and any formula or instruction contained in the article will not, if followed accurately, cause any injury, illness or damage to the user.
- I, and all co-authors, agree that the article, if editorially accepted for publication, shall be licensed under the Creative Commons Attribution-NonCommercial 4.0 International License
- I, and all co-authors, agree that, if the article is editorially accepted for publication in Journal of Applied Pharmaceutical Research (JOAPR) data included in the article shall be made available under the Creative Commons 1.0 Public Domain Dedication waiver, unless otherwise stated. For the avoidance of doubt it is stated that sections 1, 2, and 3 of this license agreement shall apply and prevail.
